Related Products of 19798-80-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19798-80-2, name is 4-Chloropyridin-2-amine. A new synthetic method of this compound is introduced below.
Step A: tert-Butyl 4-chloropyridin-2-ylcarbamate To a solution 4-chloropyridin-2-amine (2.56 g, 20 mmol), lithium bis(trimethylsilyl) azanide (LiHMDS) (6.68 g, 40 mmol) in anhydrous THF (25 mL) was added Boc20 (4.36 g, 20 mmol). The resulting mixture was allowed to stir at -5 C for 2 hours. The reaction mixture was quenched with water (5 mL), extracted with EtOAc (3 x 10 mL), dried over Na2S04, filtered and concentrated. The crude residue was purified by column chromatography to afford the title compound as a white solid. LC/MS m/z = 229.19 [M+H]+
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19798-80-2, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MCCOMAS, Casey, C.; KUDUK, Scott, D.; REGER, Thomas, S.; WO2014/81617; (2014); A1;,
Pyridine – Wikipedia,
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