Application of 1094679-27-2, Adding some certain compound to certain chemical reactions, such as: 1094679-27-2, name is 4-Ethynylpyridin-2-amine,molecular formula is C7H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1094679-27-2.
To a solution of (4-(3-iodoimidazo[l,2-a]pyrazin-6- yl)phenyl)(morpholino)methanone (180 mg, 0.41 mmol) in acetonitrile (3 mL) was added 4-ethynylpyridin-2 -amine (95.9 mg, 0.62 mmol), Pd(PPh3)4 (24.3 mg, 0.021 mmol), Cul (7.8 mg, 0.041 mmol) and DIPEA (1.5 mL). The reaction mixture was heated at 85 C for 1.5 h under nitrogen. The resulting mixture was diluted with dichloromethane (50 mL), filtered through celite and concentrated under reduced pressure. The residue was purified by flash column chromatography (silica gel, 100% DCM to DCM/Methanol 96:4). The fractions containing the products were concentrated under reduced pressure. The residue was diluted with DCM (50 mL) and washed with saturated sodium bicarbonate solution (2 x 5 mL). The combined organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure to afford (4-(3-((2-aminopyridin-4- yl)ethynyl)imidazo[l,2-a]pyrazin-6-yl)phenyl)(morpholino)methanone (93 mg, 0.22 mmol, 53.4 %, AUC HPLC 99.46 %) as light yellow solid mp: 143.5-144.2 C. H NMR (400 MHz, CDC13) delta (ppm): 9.22 (d, J = 1.2 Hz, 1H), 8.58 (d, J = 1.2 Hz, 1H), 8.14 (d, J = 4.8 Hz, 1H), 8.10-8.05 (m, 3H), 7.57 (d, J = 8.4 Hz, 2H), 6.83 (dd, J = 5.2; 1.2 Hz, 1H), 6.69 (s, 1H), 4.61 (s, 2H), 4.00-3.40 (m, 8H); MS (ESI) m/z 425.10 [C24H20N6O2 + H]+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1094679-27-2, 4-Ethynylpyridin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH; NACRO, Kassoum; CHENNAMANENI, Lohitha Rao; WO2015/50505; (2015); A1;,
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