Sources of common compounds: 4-Methyl-5-nitropicolinic acid

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5832-43-9, 4-Methyl-5-nitropicolinic acid, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5832-43-9, name is 4-Methyl-5-nitropicolinic acid, molecular formula is C7H6N2O4, molecular weight is 182.13, as common compound, the synthetic route is as follows.Formula: C7H6N2O4

To a solution of 4-methyl-5-nitro-2-pyridinecarboxylic acid (1.0 g, 5.5 mmol) in methanol (50 mL) was added concentrated HQ (8 mL, 97 mmol) at room temperature. The mixture was heated at reflux for 18h, then cooled to room temperature. The crude mixture was partitioned between EtOAc and saturated NaHCO3 and the aqueous layer was extracted with EtOAc (twice). The combined organic phase was washed with brine, dried over anhydrous MgS0 , filtered and concentrated to provide methyl 4-methyl-5-nitropicolinate. -NMR (CDC13, 500 MHz), delta 9.23 (s, 1H), 8.16 (s, 1H), 4.06 (s, 3H), 2.77 (s, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5832-43-9, 4-Methyl-5-nitropicolinic acid, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WALSH, Shawn, P.; CATO, Brian; FRIE, Jessica, L.; KIM, Dooseop; PASTERNAK, Alexander; SHI, Zhi-Cai; WO2014/85210; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem