Synthetic Route of 769-28-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 769-28-8, name is 4,6-Dimethyl-2-oxo-1,2-dihydropyridine-3-carbonitrile, molecular formula is C8H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1-methyl-4-cyano-5,6,7,8-tetrahydroisoquinolone (14.8 g, 0.1 mol) was added to a solution of methanol and added5g of self-manufactured Raney Nickel and 15ml of ammonia, replace it with nitrogen and replace it with hydrogen. Maintain the hydrogen pressure under confined conditionsAt 10 MPa, slowly warm up to 72C and stir overnight. Stop the reaction. After TLC monitoring reaction is complete, cool to room temperature and filter to removeAgents. The reaction solution was concentrated in vacuo to give a colorless oil that solidified upon standing.
According to the analysis of related databases, 769-28-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Sichuan University; Puluo Pharmaceutical Co., Ltd.; Yu Luoting; Wei Yuquan; (24 pag.)CN107573327; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem