Related Products of 769-28-8 ,Some common heterocyclic compound, 769-28-8, molecular formula is C8H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
[00176] Step 2: tert-butyl ((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)methyl)carbamate: To a solution of 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3- carbonitrile (40 g, 0.27 mol) in THF/CH30H (1:1, 2 L) were added Ni (40 g), Boc20 (110 g,0.5 mol) and Et3N (50 g, 0.5 mol). Then the mixture was stirred in H2 atmosphere at roomtemperature for 48 h. The reaction solution was filtrated and concentrated to give crude product. The crude was added H20 (200 mL) and extracted by DCM (600 mL*3). The organic layer was concentrated to give tert-butyl ((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3- yl)methyl)carbamate (40 g, 56 %) for next step.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,769-28-8, its application will become more common.
Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; ALBRECHT, Brian, K.; AUDIA, James, Edmund; DAKIN, Les, A.; DUPLESSIS, Martin; GEHLING, Victor, S.; HARMANGE, Jean-Christophe; NASVESCHUK, Christopher, G.; VASWANI, Rishi, G.; WO2015/23915; (2015); A1;,
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