Reference of 936342-91-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 936342-91-5, name is 5-Bromo-2-(chloromethyl)pyridine hydrochloride, molecular formula is C6H6BrCl2N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A mixture of 5-bromo-2-methylpyridine (500mg, 2.06mmol) and 1-methanesulfonyl-piperazine (440mg, 2.68mmol) was dissolved in N, N- dimethylformamide (10ml) was then added carbonate potassium (996mg, 7.21mmol), the reaction was stirred for 12 hours at room temperature, 100ml of water was added to the reaction mixture was cooled, (100ml * 3) and extracted with ethyl acetate, then with saturated sodium chloride solution (100ml * 2) and washed to give the organic phase was dried over anhydrous magnesium sulfate filtered, and concentrated under reduced pressure to give 1- (5-bromo – 2-methyl-pyridin) yl-4-methanesulfonyl – piperazine (520mg, white solid), yield: 75.6percent.
According to the analysis of related databases, 936342-91-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SHANGHAI CDYMAX PHARMACEUTICALS CO., LTD; An, Xiaoxia; Bie, Pingyan; Liu, Jun; Yang, Wuli; (42 pag.)CN103360407; (2016); B;,
Pyridine – Wikipedia,
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