Synthetic Route of 941294-54-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.941294-54-8, name is 5-Bromo-2-methoxynicotinonitrile, molecular formula is C7H5BrN2O, molecular weight is 213.03, as common compound, the synthetic route is as follows.
Example 2 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-amine 35 ml (23.47 mmol) of hydrazine is added at room temperature to 5 g (23.47 mmol) of 5-bromo-2-methoxynicotinonitrile. The reaction medium is carried at 100 C. for 3 hours. After returning to room temperature, the precipitate obtained is filtered, rinsed with water and then dried at 50 C. to yield 3.6 g (72%) of 5-bromo-1H-pyrazolo[3,4-b]pyridine-3-amine in the form of a yellow solid. LCMS (EI, m/z): (M+1) 214.05 1H NMR: deltaH ppm (400 MHz, DMSO): 12.18 (1H, s, NH), 8.38 (1H, d, CHarom), 8.37 (1H, d, CHarom), 5.66 (2H, s, NH).
The chemical industry reduces the impact on the environment during synthesis 941294-54-8, I believe this compound will play a more active role in future production and life.
Reference:
Patent; PIERRE FABRE MEDICAMENT; KALOUN, El Bachir; BEDJEGUELAL, Karim; RABOT, Remi; KRUCZYNSKI, Anna; SCHMITT, Philippe; PEREZ, Michel; RAHIER, Nicolas; US2013/85144; (2013); A1;,
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