Adding a certain compound to certain chemical reactions, such as: 914358-72-8, 5-Bromo-3-chloro-2-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H5BrClN, blongs to pyridine-derivatives compound. HPLC of Formula: C6H5BrClN
[00443] To a solution of Example 75a (150 mg, 0.33 mmol), Example 75b (75 mg, 0.36 mmol) in 1,4- dioxane/H20 (4 mL/1 mL) were added Pd(dppf)Cl2 (24 mg, 0.033 mmol) and Na2C03 (70 mg, 0.66 mmol). The mixture was degassed by nitrogen for three times and heated at 95C for 2 h. The reaction mixture was filtered, washed with EtOAc and concentrated. The residue was purified by prep-TLC (DCM/MeOH = 15/1) to give the desired product Example 75 (49.0 mg, yield 33%) as a gray solid.LCMS [M/2+l]+ = 231.0. NMR (400 MHz, DMSO- 6) 5 11.18 (s, 1H), 8.73 (d, J= 2.1Hz, 1H), 8.68 (s, 1H), 8.24 (d, J= 2.6 Hz, 1H), 8.18 (d, J= 2.1Hz, 1H), 8.04 (d, J= 7.9 Hz, 1H), 7.98 (dd, J= 8.7, 2.6 Hz, 1H), 7.86 (dd, J= 13.0, 7.8 Hz, 2H), 7.39 (d, J= 8.6 Hz, 1H), 4.36 (t, J= 5.0 Hz, 2H), 4.30-4.20 (m, 2H), 2.56 (s, 3H), 2.43 (br, 2H), 1.96 (d, J= 7.1Hz, 2H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,914358-72-8, 5-Bromo-3-chloro-2-methylpyridine, and friends who are interested can also refer to it.
Reference:
Patent; FRONTHERA U.S. PHARMACEUTICALS LLC; JIN, Bohan; DONG, Qing; HUNG, Gene; (214 pag.)WO2019/51265; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem