Adding a certain compound to certain chemical reactions, such as: 757978-18-0, 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 757978-18-0, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Bromo-3-iodo-1H-pyrrolo[2,3-b]pyridine
100 mL round bottom flaskIodo-1H-pyrrole [2,3-b] pyridine (M1) (100.0 mg, 3.1 mmol)20 mL of dichloromethane, triethylamine (930 mg, 9.2 mmol), DMAP (40 mg, 0.31 mmol),Benzenesulfonyl chloride (N1) (1100 mg, 6.2 mmol) was dissolved in 10 mL of dichloromethane under ice-cooling,Dropping funnel through the constant pressure drop into the solution, the drop is completed, stirring at room temperature 1h,TLC detection, no M1 remaining, washed 3 times, liquid separation, the organic phase anhydrous sodium sulfate drying,The solvent was removed by concentration and recrystallized from ethyl acetate (5 mL) to give a white solid which was dried to give 5-bromo-3-iodo-1- (phenylsulfonyl) -1H-pyrrole [2,3-b] pyridine (B8).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,757978-18-0, its application will become more common.
Reference:
Patent; Fudan University; Zhou, Yaming; Yang, Chengbin; Hong, Hui; Liu, Xiaofeng; Yang, Yongtai; Ling, Yun; Gu, Yu; Deng, Mingli; (38 pag.)CN106117181; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem