Synthetic Route of 89488-30-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89488-30-2, name is 5-Bromo-3-methylpyridin-2(1H)-one. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 1-(1-benzyl-5-methyl-1H-pyrazol-4-yl)-2-bromoethan- 1-one (590 mg), 5-bromo-3-methylpyridin-2-ol (378 mg), K2CO3 (555.60 mg, 4.02 mmol) and DMSO (10 mL) was stirred at room temperature overnight. The mixture was quenched with water and the resulting solid was collected by filtration and washed with water. The solid was recrystallized from DMSO/water to give the target compound (460 mg) as a solid. (1380) [00534] 1H NMR (500 MHz, DMSO-d6): ^ 8.29 (s, 1H), 7.83 (dd, J = 2.7, 0.9 Hz, 1H), 7.53 (dq, J = 2.3, 1.1 Hz, 1H), 7.40-7.35 (m, 2H), 7.34-7.29 (m, 1H), 7.19-7.15 (m, 2H), 5.43 (s, 2H), 5.22 (s, 2H), 2.50 (s, 3H), 2.01 (t, J = 0.9 Hz, 3H).
According to the analysis of related databases, 89488-30-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; HLA, Timothy; JILISHITZ, Irina; MEINKE, Peter; STAMFORD, Andrew; FOLEY, Michael; SATO, Ayumu; WADA, Yasufimi; FUKASE, Yoshiyuki; KINA, Asato; TAKAHAGI, Hiroki; IGAWA, Hideyuki; POLVINO, William J.; (0 pag.)WO2019/173790; (2019); A1;,
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