Adding a certain compound to certain chemical reactions, such as: 13466-38-1, 5-Bromopyridin-2-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Bromopyridin-2-ol, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Bromopyridin-2-ol
[00320] A round bottom flask was charged with 2-hydroxy-5-bromopyridine (1.0 g, 5.7 mmol) and 1,2-dimethoxy ethane (30 mL) and potassium tert-butoxide (0.65 g, 5.7 mmol) was added and the reaction mixture stirred at room temperature for 30 minutes, potassium carbonate (0.56 g, 4.0 mmol) and l-Boc-3-bromomethylazetidine (2.88 g, 11.5 mmol) were added and the reaction mixture heated to reflux overnight. The reaction mixture was cooled to room temperature and quenched with water and extracted with ethyl acetate (3X100 mL). The combined organics were washed with brine and dried over MgS04. The solvents were evaporated to dryness and the residue purified by flash chromatography (40 g silica, 0-100% ethyl acetate in hexanes) to give the product as white solid (1.65 g, 84%). LC/MS: [M+] 343.2; 1H MR (300 MHz, CDC13): delta 7.39-7.34 (m, 2H), 6.49 (d, J=9.3 Hz, IH), 4.08-3.97 (m, 4H), 3.72-3.67 (m, 2H), 3.07-3.05 (m, IH), 1.44 (s, 9H),
The synthetic route of 13466-38-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; FGH BIOTECH, INC.; HUFF, Joel; UESUGI, Motonari; KINCAID, John; (213 pag.)WO2017/190086; (2017); A1;,
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