Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 112110-07-3, name is 5-(Trifluoromethyl)pyridin-3-amine. A new synthetic method of this compound is introduced below., Recommanded Product: 112110-07-3
289 mg of compound (IIb-13)And 0.95eq5-trifluoromethyl-3-aminopyridine weighed in a sealed tube,0.1 eq tris (dibenzylidene indenone) dipalladium,0.2eqX-phos, 1.39eq CS2CO3,5 ml of dioxane was added,Replace N2 protection,After the reaction at 50 24h move to room temperature,cool down.The reaction solution was filtered,100 ml of ethyl acetate,100ml saturated NaCl wash,Dry and spin dry,PE: EA = 5: 1 After column separation,277.3 mg of product (IIc-17)The yield is 86.03%.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 112110-07-3, 5-(Trifluoromethyl)pyridin-3-amine.
Reference:
Patent; Sichuan University; Zhang Tao; Wang Fangying; Chen Yuanwei; Wei Yuquan; (41 pag.)CN107382840; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem