Adding a certain compound to certain chemical reactions, such as: 112110-07-3, 5-(Trifluoromethyl)pyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 5-(Trifluoromethyl)pyridin-3-amine, blongs to pyridine-derivatives compound. Quality Control of 5-(Trifluoromethyl)pyridin-3-amine
1-{r(5S,7S)-2-Oxo-3-(2-propyn-1-yl)-1-oxa-3-azaspiror4.5ldec-7-yllmethyl)-1 H-benzimidazole-6- carbonitrileTo a solution of 5-(trifluoromethyl)-3-pyridinamine (0.150 g, 0.925 mmol) in EtOAc (3 mL) at 0 C was added concentrated HCl (0.5 mL). The reaction mixture was stirred for 10 min, then a solution of sodium nitrite (0.192 g, 2.78 mmol, 3 eq; dissolved in 1 mL of water) was added over 2 min. The reaction mixture was then stirred for 30 min. A solution of sodium azide (0.180 g, 2.78 mmol) (3 eq; dissolved in 1 mL of water) was then added over 5 min. After 1 h, a solution of 10% Na2C03 was added to the mixture to make the solution a pH 9-10. The mixture was then extracted with EtOAc (2 x 10 mL). Organic layers were dried over MgS04, filtered, and concentrated in vacuo. The product was placed in high vacuum for 30 min. 1-{[(5S,7S)-2-oxo-3- (2-propyn-1-yl)-1-oxa-3-azaspiro[4.5]dec-7-yl]methyl}-1 H-benzimidazole-6-carbonitrile was obtained as a low viscosity dark orange oil (100 mg, 57% yield).
The synthetic route of 112110-07-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE LLC; BROOKS, Carl; CHEUNG, Mui; EIDAM, Hilary, Schenck; GOODMAN, Krista, B.; HAMMOND, Marlys; HILFIKER, Mark, A.; HOANG, Tram, H.; PATTERSON, Jaclyn, R.; STOY, Patrick; YE, Guosen; WO2013/12500; (2013); A1;,
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