In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 55717-45-8, name is 6-Bromopyridin-3-ol, the common compound, a new synthetic route is introduced below. Application In Synthesis of 6-Bromopyridin-3-ol
[000570] Synthesis [000571] A mixture of 2 (579 mg, 3.46 mmol), 1 (500 mg, 2.89 mmol) and K2C03 (1.2 mg, 8.7 mmol) in 5 mL of DMF was stirred at 60 C for 16 hours. The reaction mixture was diluted with water (50 mL) and extracted with ethyl acetate (40 mL x 3). The combined organic phases were washed with water (50 mL), brine (50 mL), dried over anhydrous Na2SC>4 and filtered. The filtration was concentrated in vacuo, and the residue was purified by silica gel chromatography (ethyl acetate: petroleum ether = 10: 1) to give 3 as white solid (650 mg, yield: 85.5%). LC-MS m/z: 266.0 [M+H]+. LC-MS Purity (254 nm): > 81%; tR= 1.964 min.
The synthetic route of 55717-45-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James; ERB, Michael; QI, Jun; (96 pag.)WO2016/196879; (2016); A1;,
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