Reference of 57963-08-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 57963-08-3, name is 5,6-Dimethylpyridin-2-amine. A new synthetic method of this compound is introduced below.
Example 2 (3S)-2-((2R)-3-Cyclopentyl-2-{[formyl(hydroxy)amino]methyl}propanoyl)-N-(3,4-dimethyl-2-pyridinyl)-3-pyrazolidinecarboxamide 2-amino-5,6-dimethylpyridine (68.2 mg, 0.558 mmol). LC/MS: (M+H)+: 417.9. 1H NMR (400 MHz, METHANOL-d4) ppm 1.04-1.26 (m, 2H) 1.32-1.48 (m, 1H) 1.48-1.69 (m, 4H) 1.69-1.99 (m, 4H) 2.14-2.32 (m, 4H) 2.41 (s, 3H) 2.46-2.62 (m, 1H) 2.80-3.01 (m, 1H) 3.16-3.31 (m, 1H) 3.51 (dd, J=14.15, 4.55 Hz, 1H) 3.62-3.86 (m, 2H) 3.95 (dt, J=9.35, 4.67 Hz, 1H) 4.57-4.79 (m, 1H) 7.49 (d, J=8.34 Hz, 1H) 7.80 (d, J=8.08 Hz, 1H) 7.88 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,57963-08-3, its application will become more common.
Reference:
Patent; GlaxoSmithKline Intellectual Property (No. 2) Limited; Aubart, Kelly M.; Benowitz, Andrew B.; Fang, Yuhong; Hoffman, James; Karpinski, Joseph M.; Knox, Andrew Nicholson; Liao, Xiangmin; Qin, Donghui; Shi, Dongchuan; Spletstoser, Jared T.; US8901119; (2014); B2;,
Pyridine – Wikipedia,
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