Electric Literature of 1187322-51-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1187322-51-5, name is 6-Amino-5-iodonicotinonitrile, molecular formula is C6H4IN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
1.2 g 5-[4-(6-trimethylsilanyl-hex-5-ynyl)-piperazin-1-yl]-benzofuran-2- carboxylic acid amide, 500 mg beta-amino-delta-iodo-nicotinonitrile, 0.1 g lithium chloride, 0.8 g sodium carbonate and 0.1 g 1,1′-bis(diphenyl- phosphino)ferrocenedichloropalladium- (II) dichloromethane adduct were dissolved in 50 ml DMF and heated for 12 h. The black suspension was poured on 50 ml water and extracted with ethyl acetate. After the usual extraction and purification procedure 20 mg of fawn amorphous solid 5-{4-[4-(5-cyano-1 H-pyrrolo[2,3-b]pyridine-3-yl)-butyl]- piperazin-1-yl}-benzofuran-2-carboxylic acid amide were obtained. 1H-NMR (500MHz, dbeta-DMSO) delta 12.18 (br s, 1H)1 8.49 (d, 1 H, J = 1.8 Hz), 8.33 (d, 1 H, J = 1.8 Hz), 7.99 (br. s, 1 H), 7.57 (br. s, 1 H), 7.47 (d, 1H1 J = 9.9 Hz), 7.40 (s, 1 H), 7.17 (m, 2H), 6.35 (s, 1 H), 3.33 (m, 4H), 3.11 (m, 4H)1 2.81 (m, 2H), 2.38 (m, 2H), 1.76 (m, 2H), 1.54 (m, 2H).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1187322-51-5, 6-Amino-5-iodonicotinonitrile.
Reference:
Patent; MERCK PATENT GMBH,; WO2009/112139; (2009); A1;,
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