Reference of 89466-18-2 ,Some common heterocyclic compound, 89466-18-2, molecular formula is C6H7BrN2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Acetic anhydride (11.3 mL, 120 mmol) was added dropwise to formic acid (17.0 mL, 450 mmol) then stirred at room temperature for 24 minutes. The formic acid and acetic anhydride mixture was added to 6-bromo-2-methoxypyridin-3- amine (Y1) in 50 mL of THF via cannula. The reaction was stirred at room temperature for 30 minutes. An additional 10 mL of THF was used to aid the transfer. The reaction was stirred at room temperature for 2h. The reaction was quenched with 140 mL of ice cold water. This solution was then filtered leaving a white solid. The solid was rinsed with additional water, dried on the filter, then left under vacuum overnight to yield 5.04g (70%) of the formamide (Y2). 1H NMR (CDCI3 400 MHz) delta 8.45-8.43 (m, 2H), 7.61 (br s, 1 H), 7.08 (d, J = 8.0 Hz, 1 H), 4.03 (s, 3H). MS: M+1 = 231.0.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89466-18-2, its application will become more common.
Reference:
Patent; SCHERING CORPORATION; ZHU, Zhaoning; GREENLEE, William, J.; LI, Hongmei; VICAREL, Monica, L.; QIN, Jun; DHONDI, Pawan, Kumar; HUANG, Xianhai; PALANI, Anandan; LIU, Xiaoxiang; SUN, Zhong-Yue; JOSIEN, Hubert B.; XU, Ruo; COLE, David, James; BURNETT, Duane, A.; BENNETT, Chad, E.; MCCRACKEN, Troy, M.; MACCOSS, Malcolm; WO2010/56722; (2010); A1;,
Pyridine – Wikipedia,
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