Adding a certain compound to certain chemical reactions, such as: 139585-70-9, 6-Bromonicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H3BrN2, blongs to pyridine-derivatives compound. HPLC of Formula: C6H3BrN2
0.54 g of intermediate 3-1,0.28 g of 2-bromo-5-cyanopyridine, 1.28 g of tripotassium phosphate,And 0.15 g of [1,1-bis (diphenylphosphino) ferrocene] palladium dichloride,10 mL of DME was added. The mixture was stirred at 80 C. for 2 hours,After cooling to room temperature, water was added and the mixture was extracted with ethyl acetate.The obtained organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure.The obtained residue was subjected to silica gel chromatography (hexane: ethyl acetate = 1: 3) to obtain 0.26 g of the active compound A-52 shown below.
The synthetic route of 139585-70-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; MURAKAMI, SHINICHIRO; (291 pag.)JP2018/76354; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem