Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33674-96-3, name is (6-Bromopyridin-2-yl)methanol. A new synthetic method of this compound is introduced below., Recommanded Product: 33674-96-3
To a solution of (6-bromo-pyridin-2-yl)-methanol (2.00 g; 10.64 mmol) in 15 mL of dichloromethane is added dropwise phosphorus tribromide (0.61 mL; 6.44 mmol) at 0C. The mixture is warmed to room temperature and stirred overnight. Additional 100 muL of phosphorus tribromide is added and the reaction mixture is stirred for 3 hours at room temperature. The reaction is quenched with cooled NaHCO3 (half saturated aqueous solution) and extracted two times with dichloromethane. The combined organic layers are dried and concentrated under reduced pressure. (0563) Yield: 2.44 g (91 % of theory) (0564) Mass spectrometry (ESI+): m/z = 250/252 [M+H]+ (Br) (0565) HPLC (Method 1): Retention time = 0.878 min.
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Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; TRIESELMANN, Thomas; GODBOUT, Cedrickx; HOENKE, Christoph; VINTONYAK, Viktor; (130 pag.)WO2019/149660; (2019); A1;,
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