Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6265-73-2, name is N-(2-Hydroxyethyl)nicotinamide. A new synthetic method of this compound is introduced below., HPLC of Formula: C8H10N2O2
Example 42 A mixture of 10-(2,3-dimethylpentanoylamino)-7-methyl-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylic acid (250 mg) and thionyl chloride (4 ml) was stirred at 10C for 30 minutes. The reaction mixture was stirred for 1 hour at room temperature, and then evaporated to dryness in vacuo to give an acid chloride. A mixture of the acid chloride, pyridine (0.1 ml) and dry dichloromethane (60 ml) was cooled to 5C. A solution of N-(2-hydroxyethyl)nicotinamide (108 mg) in dry dichloromethane was added to the mixture. The reaction mixture was stirred at 5C for 1 hour, and allowed to stand at room temperature overnight. The reaction mixture was diluted with chloroform-methanol, and washed with water and brine, dried over magnesium sulfate and evaporated in vacuo. The residue was subjected to a column chromatography on silica gel with chloroform-methanol. The elude was concentrated in vacuo to give residue, which was recrystallized from chloroform-ether to give 2-(nicotinamido)ethyl 7-methyl-10-(2,3-dimethylpentanoylamino)-4-oxo-4H-pyrimido[2,1-a]isoquinoline-3-carboxylate (0.26 g). mp: 204-210C IR (Nujol): 3250, 1730, 1650, 1630, 1226, 1120, 1060, 800 cm-1 NMR (DMSO-d6, delta): 0.5-2.0 (13H, m), 3.27 (3H, s), 3.70 (2H, m), 4.42 (2H, m), 7.3-9.4 (10H, m), 10.32 (1H, s)
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Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; EP143001; (1991); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem