Adding a certain compound to certain chemical reactions, such as: 6318-51-0, (4-Chlorophenyl)(pyridin-2-yl)methanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 6318-51-0, blongs to pyridine-derivatives compound. SDS of cas: 6318-51-0
General procedure: Dissolve the catalyst and potassium tert-butoxide in a mixed solvent of dichloromethane and isopropanol, mix well, then add the ketone compound A1 and stir at the temperature indicated by C1 for C2 time to obtain a third reaction solution, wherein the catalyst is relatively The molar percentage of the compound is B1, the molar percentage of potassium tert-butoxide relative to the ketone compound is B2, and the volume ratio of isopropyl alcohol and dichloromethane is D1.Filtering the third reaction solution to obtain an organic filtrate, and adding saturated saline to the organic filtrate to wash the organic filtrate, and then adding anhydrous sodium sulfate to dry the organic filtrate; A third filtrate was obtained.The third filtrate was distilled under reduced pressure to obtain a crude product of a chiral alcohol compound.The specific parameters in the preparation of alcohol compounds in Examples 2-1 to 2-18 are shown in Table 2:
At the same time, in my other blogs, there are other synthetic methods of this type of compound,6318-51-0, (4-Chlorophenyl)(pyridin-2-yl)methanone, and friends who are interested can also refer to it.
Reference:
Patent; South University of Science and Technology of China; Xing Xiangyou; Xu Chen; Pan Yupeng; Chen Fumin; He Dongxu; (31 pag.)CN110526944; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem