641569-94-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 641569-94-0, name is 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid. A new synthetic method of this compound is introduced below.
The compound of formula VI (3.5 g), Toluene (35 ml),Thionyl chloride (14 ml) was added to the reaction flask, The temperature was raised to 80 C for 5 h. The reaction solution was spin-dried, A solution of 3- (4-ethyl-1H-imidazol-1-yl) -5- (trifluoromethyl) aniline (2.0 g) Acetonitrile (70 ml), The temperature was raised to 80 C for 7 h. The reaction solution was concentrated, To give a black oil, The black oil was separated and purified on a silica gel column, The eluent is dichloromethane: Methanol = 30: 1, Collect products, Concentration gave 2.9 g of the compound of formula II, The molar yield was 69% and the HPLC purity was 98.40%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 641569-94-0, 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jiangsu Xiansheng Pharmaceutical Co., Ltd.; Guo Qi; Huang Junjie; Liao Mingyi; (7 pag.)CN106905298; (2017); A;,
Pyridine – Wikipedia,
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