Synthetic Route of 6602-32-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6602-32-0, name is 2-Bromo-3-hydroxypyridine, molecular formula is C5H4BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
EXAMPLE 3; MeI, K2CO3 NaOMe DMF DMF M 3-2 3.3 3-5 2:62-bromo-3 -hvdroxv-6-iodopvridine (3 -2)To a solution of 2-bromo-3 -hydroxy pyridine (3A., 28 g, 161 mmol) in water (360 mL) was added K2CO3 (44.5 g, 322 mmol) and I2 (40.8 g, 161 mmol). The system was stirred for 1.5h at ambient temperature, cooled to 00C and then treated with concentrated HCl until solids precipitated from solution (pH~ 6.0). The solids were isolated by filtration and dried to give the title compound Q1Z) as a brown solid. ESI+ MS C5H3BrINO: 299.8 found, 299.9 required.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6602-32-0, 2-Bromo-3-hydroxypyridine.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BERGMAN, Jeffrey, M.; COLEMAN, Paul, J.; MATTERN, Mamio Christa; MERCER, Swati, P.; REGER, Thomas, S.; ROECKER, Anthony, J.; WO2010/51236; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem