Sources of common compounds: 70416-53-4

At the same time, in my other blogs, there are other synthetic methods of this type of compound,70416-53-4, 5-Formylnicotinonitrile, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.70416-53-4, name is 5-Formylnicotinonitrile, molecular formula is C7H4N2O, molecular weight is 132.12, as common compound, the synthetic route is as follows.COA of Formula: C7H4N2O

INTERMEDIATE 76 PREPARATION OF 5-[(1E)-3-OXOPROP-1-EN-1-YL]PYRIDINE-3-CARBONITRILE A mixture of 5-formylpyridine-3-carbonitrile (1.82 g, 13.78 mmol) and (formylmethylene)triphenylphosphorane (4.28 g, 14.06 mmol) in DMSO (15 mL) was stirred overnight at 120 oC under a nitrogen atmosphere. After being cooled to room temperature, the reaction mixture was diluted with water (30 mL) and extracted with EtOAc (3 x 20 mL). The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography (EtOAc-petroleum ether, 1:3) to afford the title compound (490 mg, 22%) as a white solid.1H NMR (300 MHz, CDCl3) delta 9.79 (d, J = 7.2 Hz, 1H), 8.99 (d, J = 2.1 Hz, 1H), 8.92 (d, J = 2.1 Hz, 1H) 8.14 (m, 1H), 7.52 (d, J = 15.6 Hz, 1H), 6.87-6.79 (m, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,70416-53-4, 5-Formylnicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; DENALI THERAPEUTICS INC.; BONANOMI, Giorgio; ESTRADA, Anthony A.; FENG, Jianwen A.; FOX, Brian; LESLIE, Colin Philip; LYSSIKATOS, Joseph P.; NAPOLITANO, Carmela; POZZAN, Alfonso; SUDHAKAR, Anantha; SWEENEY, Zachary K.; TONELLI, Federica; DE VICENTE FIDALGO, Javier; (232 pag.)WO2017/96301; (2017); A1;,
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