In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 71670-70-7, name is 2-(Chloromethyl)-5-methylpyridine hydrochloride, the common compound, a new synthetic route is introduced below. Application In Synthesis of 2-(Chloromethyl)-5-methylpyridine hydrochloride
Example 100 l -(3-hydroxybutyl)-3-methyl-7-((5-methylpyridin-2-yl)methyl)-8-(3- (trifl To a solution of l -(3-hydroxybutyl)-3-methyl-8-(3-(trifluoromethoxy)phenoxy)-lH-pur ne- 2,6(3H,7H)- dione (50 mg, 0.121 mmol, intermediate 57) in DMF (3 mL) was added 2- (chloromethyl)-5-methylpyridine hydrochloride (30 mg, 0.182 mmol, intermediate 50), followed by potassium carbonate (50 mg, 0.363 mmol) and TBAI (10mg,0.027mmol). The reaction was stirred at 65 C overnight. The reaction was cooled and partitioned between ethyl acetate and water. The organic phase was washed with brine, dried over sodium sulfate, filtered and concentrated to give a crude product, which was purified by preparative HPLC to give l -(3- hydroxybutyl)-3-methyl-7-((5-methyl^ purine-2,6(3H,7H)-dione (20 mg, 31.9% yield) as white solid. ‘H-NMR (CD3OD) delta 8.319(s,l H), 7.663-7.640(d,l H),7.553-7.510(t,l H), 7.348-7.316(m,3H), 7.233-7.208(m, lH), 5.609(s,2H), 4.1 12-4.004(m,2H), 3.763-3.731(m, l H), 3.457(s,3H), 2.339(s,3H), 1.758- 1 .698(m,2H), 1.197-1.182(d,2H). LCMS retention time 2.714 min; LCMS MH+ 520.
The synthetic route of 71670-70-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; HYDRA BIOSCIENCES, INC.; CHENARD, Bertrand; GALLASCHUN, Randall; WO2014/143799; (2014); A2;,
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