Adding a certain compound to certain chemical reactions, such as: 73870-24-3, 4-(Bromomethyl)pyridine hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 73870-24-3, blongs to pyridine-derivatives compound. SDS of cas: 73870-24-3
Will contain compound 16 (150 mg, 0.386 mmol), Potassium carbonate (138 mg, 1.0 mmol), 4-bromomethylpyridine hydrobromide (102 mg, 0.403 mmol) the mixture with DMF (5 mL) was stirred at room temperature overnight.Water (20 mL) was added and extracted with ethyl acetate (20 mL¡Á3).The combined organic phases were washed sequentially with water (15 mL) and brine (15 mL). Dry over anhydrous sodium sulfate. Evaporate the solvent under reduced pressure.The product is purified by column chromatography (200-300 mesh silica gel,Ethyl acetate: dichloromethane = 1:1 to 10:1 elution),2-[4-Methoxy-3-(pyridin-4-ylmethoxy)-phenyl]-5,7-bis(methoxymethoxy)-4H-benzopyran-4-one (17) (144 mg).The yield was 77.8%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,73870-24-3, 4-(Bromomethyl)pyridine hydrobromide, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu Xin Element Pharmaceutical Technology Co., Ltd.; Shi Dongfang; Fu Changjin; Cheng Xi; Gong Weiwei; Gu Jie; Zhang Min; Li Pengfei; Yang Yan; Jin Wenqing; (57 pag.)CN110294732; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem