With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.771579-27-2, name is 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one, molecular formula is C8H12N2O, molecular weight is 152.1937, as common compound, the synthetic route is as follows.Product Details of 771579-27-2
[0793] Step 4: Synthesis of 3-bromo-N-((4,6-dimethyl-2-oxo-l ,2-dihydropyridin-3- yl)methyl)-l-isopropyl-6-(4-(morpholinomethyl)phenyl)-lH-pyrazolo[3,4-b]pyridine-4- carboxamide[0794] A solution of 3-bromo-l-isopropyl-6-(4-(morpholinomethyl)phenyl)-lH- pyrazolo[3,4-b]pyridine-4-carboxylic acid (0.8 g, 1.74 mmol) and 3-(aminomethyl)-4,6- dimethylpyridin-2(lH)-one (0.53 lg, 3.49 mmol) in DMSO (8 raL) and was stirred at room temperature for 15 min. Then PYBOP (1.36 g, 2.62 mmol) was added to it and stirring was continued for 12 hr. After completion of the reaction, reaction mass was poured into ice to obtain solid, which was filtered and solid was purified by silica gel column cliromatography to obtain the desired compound (39% yield). LCMS: 593.20 (M + 1)+; HPLC: 97.49% (@ 254 nm) (R,;5.338); NMR (DMSO-i?, 400 MHz) delta 1 1.48 (bs, 1H), 8.67 (t, 1H, J=4.8 Hz), 8.18 (d, 2H, J= 8.4 Hz), 7.73 (s, 1H), 7.47 (d, 2H, .1=8.4 Hz), 5.87 (s, 1H), 5.33-5.30 (m, 1 H), 4.40 (d, 2H, J= 4.4 Hz), 3.58 (bs, 4H), 3.53 (s, 2H), 2.38 (bs, 4H), 2.26 (s, 3H), 2.1 1 (s, 3H), 1.52 (d, 6H, J=6.4 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,771579-27-2, 3-(Aminomethyl)-4,6-dimethylpyridin-2(1H)-one, and friends who are interested can also refer to it.
Reference:
Patent; EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William; WO2012/118812; (2012); A2;,
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