Related Products of 82090-52-6, Adding some certain compound to certain chemical reactions, such as: 82090-52-6, name is Imidazo[1,2-a]pyridin-2-ylmethanol,molecular formula is C8H8N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 82090-52-6.
Example 21; N-{5-[(cyclopropylamino)carbonyl]-2-methylphenyl}-2-(imidazo[1,2-a]pyridin-2- ylmethoxy) pyrimidine-5-carboxamide A mixture of N- {5-[(cyclopropylanaino) carbonyl]-2-methylphenyl}-2- (methylsulfonyl) pyrimidine-5-carboxamide (120mg, 0. 32mmol), imidazo [1, 2-a] pyridine-2- methanol (48mg, 0. 32mmol) and potassium carbonate (44mg, 0. 32mmol) in THF (5mL) was heated to 67C for 3.5 h. The mixture was cooled to room temperature and partitioned between DCM and water and the layers separated. The aqueous layer was extracted with DCM and the combined organic extracts dried (Mg04), filtered and concentrated at reduced pressure to give a yellow oil. This material was purified by silica column chromatography, eluting with a gradient of 0 to 8% methanol in DCM to give the title compound as a white solid (33 mg, 23%); NMR Spectrum: (DMSOd6) 0.57 (m, 2H), 0.67 (m, 2H), 2.27 (s, 3H), 2. 83 (m, 1H), 5.70 (s, 2H), 7.26 (t, 1H), 7.35 (d, 1H), 7.66 (m, 2H), 7.78 (d, 1H), 7. 83 (d, 1H), 8.30 (s, 1H), 8. 38 (d, 1H), 8. 75 (d, 1 H), 9. 17 (s, 2H), 10.16 (s, 1H) ; Mass Spectrum : M-H- 441, M+H+ 443.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 82090-52-6, Imidazo[1,2-a]pyridin-2-ylmethanol, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/61465; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem