With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.849068-61-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid, molecular formula is C8H5BrN2O2, molecular weight is 241.04, as common compound, the synthetic route is as follows.Application In Synthesis of 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid
To a solution of 5-bromo-lH-pyrrolo [2,3-b] pyridine-3-carboxylic acid (600 mg, 2.49 mmol)Of N, N-dimethylformamide (20 mL)To the solution was added 1- (3-dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (1.44 g, 7.43 mmol)1-hydroxybenzotriazole (1.01 g, 7.46 mmol) and2-isopropylamine (1.27 mL, 14.90 mmol),Stir overnight at room temperature.Saturated brine (20 mL) was added,Dichloromethane (15 mL x 3)Dried over anhydrous sodium sulfate, the solvent was removed,The concentrate was subjected to column chromatography (eluent: petroleum ether / ethyl acetate (v / v) = 5/1) to give the product as360 mg of a brown solid, yield: 51.3%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,849068-61-7, 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid, and friends who are interested can also refer to it.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Huang Jiuzhong; Zheng Changchun; Zhang Yingjun; Ouyang Luo; Mao Hongfen; Nie Biao; Xu Juan; Chen Hongfen; (137 pag.)CN106336413; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem