With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.865156-50-9, name is (4-Bromopyridin-2-yl)methanamine, molecular formula is C6H7BrN2, molecular weight is 187.04, as common compound, the synthetic route is as follows.Application In Synthesis of (4-Bromopyridin-2-yl)methanamine
Preparation 72 tert-butyl [(4-bromopyridin-2-yl)methyl]carbamate Di-tert-butyl dicarbonate (4 g, 18.28 mmol), triethylamine (3 mL, 21.93 mmol) and 4- dimethylaminopyridine (40 mg, 0.36 mmol) were added to a solution of 1-(4- bromopyridin-2-yl)methanamine (Preparation 73, 1.9 g, 10.1 mmol) in dichloromethane (40 mL) and the reaction mixture was stirred for 18 hours. The mixture was quenched with water (50 mL), extracted with dichloromethane (100 mL) and the organic layer was dried over magnesium sulfate and solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography eluting with 1 : 1 ethyl acetate:heptane to give the title compound as a colourless oil (1.99 g, 95%). (0982) 1 H NMR (400MHz, CDCI3): delta ppm 1.46 (s, 9H), 4.42 (d, 2H), 5.45 (br s, 1 H), 7.34-7.36 (m, 1 H), 7.45 (s, 1 H), 8.34 (d, 1 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,865156-50-9, (4-Bromopyridin-2-yl)methanamine, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER INC.; SWAIN, Nigel Alan; BROWN, Alan Daniel; JONES, Lyn Howard; MARRON, Brian Edward; RAWSON, David James; RYCKMANS, Thomas; STORER, Robert Ian; WEST, Christopher William; WO2015/181797; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem