Adding a certain compound to certain chemical reactions, such as: 874959-68-9, 5-Bromopyridine-2-sulfonyl chloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 874959-68-9, blongs to pyridine-derivatives compound. SDS of cas: 874959-68-9
5-Bromo-N-(4-methoxy-6-methyl-pyrimidin-2-yl)pyridine-2-sulfonamide (Intermediate Z) (0442) [00301] To a solution of 5-bromopyridine-2-sulfonyl chloride (1.00 g, 3.90 mmol, Intermediate W) in pyridine (10 mL) was added 4-methoxy-6-methyl-pyrimidin-2-amine (542 mg, 3.90 mmol). The reaction mixture was stirred at 15 C for 16 hrs. On completion, the reaction mixture was concentrated in vacuo and the residue was triturated with dichloromethane:methanol = 5:1 to give the title compound which was used directly without further purification. LCMS: (ES+) m/z (M+H)+ = 360.8, tR= 0.965.1H NMR (400MHz, DMSO- d6) delta = 12.96 (br. s., 1H), 8.75 (d, J = 1.6 Hz, 1H), 8.26 (dd, J = 1.8, 8.3 Hz, 1H), 7.99 (d, J = 8.3 Hz, 1H), 6.15 (s, 1H), 3.43 (s, 3H), 2.23 (s, 3H).
The synthetic route of 874959-68-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; RAZE THERAPEUTICS, INC.; MAINOLFI, Nello; MOYER, Mikel P.; SAIAH, Eddine; (264 pag.)WO2017/156181; (2017); A1;,
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