Synthetic Route of 875232-70-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.875232-70-5, name is 2,4-Dibromo-5-chloropyridine, molecular formula is C5H2Br2ClN, molecular weight is 271.3371, as common compound, the synthetic route is as follows.
Methyl 4′-amino-5′-methoxy-2′-methylbiphenyl-4-carboxylate generated in Step 1 (200 mg, 0.75 mmol), 2,4-dibromo-5-chloropyridine (222 mg, 0.82 mmol, 1.1 equiv), Pd2(dba)3 (17 mg, 0.02 mmol, 0.025 equiv.), xantphos (22 mg, 0.04 mmol, 0.05 equiv.), and Cs2CO3 (365 mg, 1.1 mmol, 1.5 equiv.) are added to THF (5 mL). The resulting mixture is bubbled with N2 gas for 5 minutes and then heated at 150 0C for 4 hours. After cooling to room temperature, the reaction mixture is diluted into EtOAc and washed with H2O. The EtOAc layer is dried over Mg2SO4 and concentrated in vacuo. Silica gel chromatography (hexanes-EtOAc) affords Methyl 4′-(4-bromo-5-chloropyridin-2-ylamino)-5′-methoxy-2′-methylbiphenyl-4-carboxylate; MS m/z 461.0 (M+l).
The chemical industry reduces the impact on the environment during synthesis 875232-70-5, I believe this compound will play a more active role in future production and life.
Reference:
Patent; IRM LLC; WO2008/73687; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem