Adding a certain compound to certain chemical reactions, such as: 885168-20-7, 2-Bromo-5-fluoro-4-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H5BrFN, blongs to pyridine-derivatives compound. Computed Properties of C6H5BrFN
5-fluoro-4-methyl-pyridine-2-carboxylic acid methyl ester18 g 2-bromo-5-fluoro-4-methyl-pyridine, 1.5 g 1, ?-bis (diphenylphosphino) ferrocene dichloropalladium (II) and 18 g sodium acetate was stirred 17 h at 80C and 5 bar carbon monoxide. The reaction was filtered and the solvent was removed. Diethylether was added to the residue and the mixture was filtered. The filtrate was evaporated to give 12 g desired product. Rt: 0.90 min. (method AB)(M+H)+: 170
The synthetic route of 885168-20-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; WO2013/79460; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem