Synthetic Route of 934279-60-4 ,Some common heterocyclic compound, 934279-60-4, molecular formula is C7H3ClF3NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-chloro-5-trifluoromethylpyridine carbaldehyde (1.2g, 5.5mmol), obtained in step 1- 1 of Example 1 , was dissolved together with N-ethyl-N-(tetrahydro-2H-pyran-4-yl)-amine (1.3g, 16.5mmol) and K2C03 (3.03g, 22mmol), in toluene (15ml), and refluxed at 130C for 48 hrs with stirring. The reaction mixture cooled to room temperature, and added with water to terminate the reaction, followed by extraction with ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate, filtered, and concentrated. The residue was purified by chromatography to afford the title compound ( .1g, 50%). 1H NMR (400MHz, CDCI3) 8.51 (s, 1 H), 7.88 (s, 1 H), 7.79 (d, J = 2.0Hz, 1 H), 7.77 (s, 2H), 5.72 (d, J = 8.0Hz, 1 H), 4.75 (d, J = 16.0Hz, 1 H), 4.34 (d, J = 16.0Hz, 1 H), 4.00 (m, 2H), 3.46 (m, 6H), 1.86 (m, 4H), 0.93 (t, 3H), 0.63 (d, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 934279-60-4, 2-Chloro-5-(trifluoromethyl)nicotinaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; DONG-A ST CO.,LTD; PARK, Jang Hyun; SONG, Seung Hyun; CHUNG, Han Kook; KIM, Heung Jae; LEE, Ji Hye; JANG, Byeong Jun; KIM, Eun Jung; JUNG, Hae Hum; RYU, Chae Lim; HWANG, Jae-Sung; LEE, Hyung Ki; KANG, Kyung Koo; KIM, Soon Hoe; WO2014/157994; (2014); A1;,
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