Application of 936342-91-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 936342-91-5, name is 5-Bromo-2-(chloromethyl)pyridine hydrochloride. A new synthetic method of this compound is introduced below.
A mixture of 5-bromo-2-chloromethylpyridine monohydrochloride(2.43g, 10mmol) and N-Boc piperazine (2.8g, 15mmol) was dissolved in N, N- dimethylformamide (20ml), followed by addition of potassium carbonate ( 4.84g, 35mmol), stirred at room temperature for 12 hours, 200ml of water was added to the reaction mixture was cooled, (100ml * 3) and extracted with ethyl acetate, then with saturated sodium chloride solution (100ml * 2) and washed, the resulting organic phase was dried over anhydrous magnesium sulfate and filtered, concentrated under reduced pressure to give 4- (5-bromo – pyridin-2-ylmethyl) – piperazine-1-carboxylate (3G, white solid), yield: 84percent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,936342-91-5, 5-Bromo-2-(chloromethyl)pyridine hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; SHANGHAI CDYMAX PHARMACEUTICALS CO., LTD; An, Xiaoxia; Bie, Pingyan; Liu, Jun; Yang, Wuli; (42 pag.)CN103360407; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem