Reference of 94170-15-7 ,Some common heterocyclic compound, 94170-15-7, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
7-(1,1-Dioxythiomorpholinyl)-2-((3S,4S)-4-isobutylpyrrol-3-yl)pyrrolo[2,1-f][1,2,4-triazine-4(3H)-one (309.1 mg) was dissolved in DCM (6 mL).4-Aldehyde-1-methylpyridine-2(1H)-one (128.9 mg, 0.94 mmol) and sodium triacetoxyborohydride (416.5 mg, 1.965 mmol),Stir at room temperature overnight,TLC monitors the reaction completely,Add saturated aqueous sodium bicarbonate (5 mL),Extracted with DCM (3 x 10 mL),Organic phase merger,Washed (2 × 5mL),Dry over anhydrous sodium sulfate,filter,concentrate,The crude product was purified by silica gel column chromatography (DCM: MeOH=100:1-20:1)Yellow solid 7-(1,1-dioxythiomorpholinyl)-2-((3S,4S)-4-isobutyl-1-((1-methyl-2-oxo-1,2-di) Hydropyridin-4-yl)methyl)pyrrolidin-3-yl)pyrrolo[2,1-f][1,2,4]triazin-4(3H)-one (80.0 mg, yield:19.8%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,94170-15-7, its application will become more common.
Reference:
Patent; Nanjing Yaojie Good Health Biological Technology Co., Ltd.; Wu Yongqian; Wang Lin; Yang Xiaoju; Tian Yuwei; (46 pag.)CN108341819; (2018); A;,
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