The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 94166-64-0, name is 2-Chloro-6-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H3ClN2O2
To a solution of 2-chloro-6-nitropyridine (2.0g, 22.96mmol, 1.5eq) and 3-methoxyazetidine (2.43g, 15.30mmol, l .Oeq) in dimethyl sulfoxide (20mL) was added sodium bicarbonate (2.57g, 30.60mmol, 2.0 eq). Reaction mixture was stirred at 80C for 4h. After completion of reaction, reaction mixture was transferred into water and extracted with ethyl acetate. Organic layer was combined, dried over sodium sulphate and concentrated under reduced pressure to obtain crude material. This was further purified by column chromatography and compound was eluted in 20% ethyl acetate in hexane as eluant to obtain pure 98.1 (2.0g, 62.47 %). MS(ES): m/z 210.21 [M+H]+
With the rapid development of chemical substances, we look forward to future research findings about 94166-64-0.
Reference:
Patent; NIMBUS LAKSHMI, INC.; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine C.; LEIT DE MORADEI, Silvana Marcel; MASSE, Craig E.; MCLEAN, Thomas H.; MONDAL, Sayan; (401 pag.)WO2018/71794; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem