Related Products of 5453-67-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5453-67-8, name is Dimethyl pyridine-2,6-dicarboxylate, molecular formula is C9H9NO4, molecular weight is 195.17, as common compound, the synthetic route is as follows.
A suspension of dimethyl pyridine-2,6-dicarboxylate (1.0 g, 5.12 mmol) in methanol (8 mL) and THF (3 mL) was heated at 75C until the solid was dissolved.NaBH4 (184 mg, 4.87 mmol) was then added portion-wise. The mixture was stirred at70C for 1 h. The mixture was cooled to room temperature and 10% citric acid (1.6 mL)was added. The solution was filtered and the filtrate was evaporated to dryness, taken upin dichloromethane, dried over Mg504 and the solvent was removed in vacuo. Theresidue was purified by silica gel chromatography, eluting with 0-100% EtOAc in isohexane, to provide a colourless oil which was then dissolved in toluene (20 mL) and chloroform (20 mL). Mn02 (194 mg, 22.2 mmol) was added and the mixture was stirred at room temperature for 18 h. The mixture was filtered through a pad of fluorosil, eluting with chloroform (30 mL) and the solvent was removed in vacuo to provide the titlecompound (249 mg, 29%) as white solid.?H NMR (400 MHz, CDC13): oe 10.20 (s, 1 H), 8.37 (dd, J = 1.2, 7.6 Hz, 1 H), 8.17(dd, J = 1.2, 7.6 Hz, 1 H), 8.08-8.04 (m, 1 H), 4.07 (s, 3 H).
Statistics shows that 5453-67-8 is playing an increasingly important role. we look forward to future research findings about Dimethyl pyridine-2,6-dicarboxylate.
Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; AMARI, Gabriele; ARMANI, Elisabetta; GHIDINI, Eleonora; BAKER-GLENN, Charles; VAN DE POeEL, Herve; WHITTAKER, Ben; WO2015/82616; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem