With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.103041-38-9, name is Ethyl 3-(pyridin-2-ylamino)propanoate, molecular formula is C10H14N2O2, molecular weight is 194.23, as common compound, the synthetic route is as follows.COA of Formula: C10H14N2O2
The embodiment of the 6 products obtained 10g, adding tetrahydrofuran 100 ml dissolved, adding 3.2gDBU, 4 . 5g3 – (pyridin-2-yl amino) propionic acid ethyl ester, the temperature is increased to 50 C reaction 7 hours, TLC (developing solvent: ethyl acetate: petroleum ether = 4:1) determine the end point of the reaction. After the completion of reaction, concentrating under reduced pressure to dry. Residue using ethyl acetate 150 ml dissolved, water 100 ml washing secondary, after drying with anhydrous sodium sulfate concentrated under reduced pressure to dry. Residue plus isopropanol refining to obtain a target compound product, yield 82.6%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,103041-38-9, Ethyl 3-(pyridin-2-ylamino)propanoate, and friends who are interested can also refer to it.
Reference:
Patent; Chongqing Institute of Pharmaceutical Industry Co., Ltd.; Xing, Naiguo; Wang, Li; Cai, Pengfei; Zheng, Deping; (14 pag.)CN105523999; (2016); A;,
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