In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 124870-33-3, name is Methyl 2-(3-cyanopyridin-4-yl)acetate, the common compound, a new synthetic route is introduced below. HPLC of Formula: C9H8N2O2
1.58g of (3-cyano-pyridine-4-yl) -acetic acid methyl ester was dissolved in 18 mL of ethanol and slowly added with 682mg of sodium borohydride at-0 C and stirred for about 2 hours. The above mixture was added with 3 mL of saturated solution of ammonium chloride, diluted with 200 mL ethylacetate. Then, the organic solvent layer was washed with water, and saturated solution of sodium chloride, dried with anhydrous sodium sulfate and filtered. The filtrate was concentreated under reduced pressure and a silica gel column chromatography was performed on the resulting residue by using a mixed eluant of methylene chloride and methanol, wherein methylene chloride and methanol are mixed in 50: 1 volume ratio, and 1.02g (74%) of 4- (2-hydroxy-ethyl)-nicotinonitrile was obtained in colorless oil. 1H NMR (300 MHz, CDCI3) 8 8. 82 (s, 1H), 8.69 (d, 1H, J=5. 4Hz), 7.39 (d, 1H, J=5. 4Hz), 3.99 (t, 2H, J=6. 3Hz), 3.10 (t, 2H, J=6. 3Hz).
The synthetic route of 124870-33-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SK CHEMICALS, CO., LTD.; WO2005/63768; (2005); A1;,
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