Electric Literature of 118650-08-1, Adding some certain compound to certain chemical reactions, such as: 118650-08-1, name is Methyl 2-(5-bromopyridin-3-yl)acetate,molecular formula is C8H8BrNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 118650-08-1.
Step 3: To a round-bottom flask containing (5-bromo-pyridin-3-yl)-acetic acid methyl ester (40 mg, 0.17 mmol), 2-[4-(2′-fluoro-2-trifluoromethyl-biphenyl-4- yloxymethyl)-phenyl]-4,4,5,5-tetramethyl-[l,3,2]dioxaborolane 13 (80 mg, 0.17 mmol), palladium acetate (6 mg, 0.026 mmol), 2-(dicyclohexylphosphino)biphenyl (18 mg, 0.051 mmol) and potassium fluoride (30 mg, 0.051 mmol) is added anhydrous 1,4-dioxane (2 ml). The flask is purged with argon and sealed. The mixture is stirred at 13O0C for 12 hours and then cooled to ambient temperature before water (5 ml) is added. The mixture is extracted with EtOAc (10 ml x 2), dried over MgSO4, and concentrated. The residue is purified by silica gel column chromatography (EtOAc/Hexane, gradient) to give {5-[4-(2′-fluoro-2- trifluoromethyl-biphenyl-4-yloxymethyl)-phenyl]-pyridin-3-yl} -acetic acid methyl ester 14: LC-MS m/z: 496.0 (M+l).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 118650-08-1, Methyl 2-(5-bromopyridin-3-yl)acetate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; IRM LLC; WO2007/24922; (2007); A1;,
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