Adding a certain compound to certain chemical reactions, such as: 1227002-03-0, Methyl 2-amino-5-chloroisonicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Methyl 2-amino-5-chloroisonicotinate, blongs to pyridine-derivatives compound. Recommanded Product: Methyl 2-amino-5-chloroisonicotinate
The reaction with methyl 2-amino-5-chloroisonicotinate takes place analogously to the reaction procedure in Example (Ik-127) using: 601 mg (3.21 mmol) of methyl 2-amino-5-chloroisonicotinate in 28.0 ml of dichloromethane, 1064 mg (3.21 mmol) of 1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazole-5-carbonyl chloride, 431 mg of silver(I) cyanide in 28.0 ml of acetonitrile. The remaining residue is purified by means of column chromatography on silica gel using the eluent mixture cyclohexane:acetone (gradient). This gives 563 mg of methyl 5-chloro-2-({[1-methyl-3-(pentafluoroethyl)-4-(trifluoromethyl)-1H-pyrazol-5-yl]carbonyl}amino)-isonicotinate (36%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1227002-03-0, Methyl 2-amino-5-chloroisonicotinate, and friends who are interested can also refer to it.
Reference:
Patent; Bayer CropScience AG; US2011/301181; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem