Application of 876919-08-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 876919-08-3, name is Methyl 3-fluoroisonicotinate, molecular formula is C7H6FNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution ofPreparation 69A (100 mg, 0.42 mmol) in DMA (5 mL) wasadded methyl3-fluoroisonicotinate (65 mg, 0.42 mmol) at rt. The reaction was stirred at170 oc for 1 h in a microwave. The reaction mixture was diluted with water extracted with EtOAc. Organics were washed with brine, dried (Na2 S04), and concentrated. Purification by silica gel chromatography (5:1 PE/EtOAc) gave 50 mg (32%) of the titlecompound as a yellow solid. 1H NMR (300 MHz, CDCh): 8 3.92 (3H, s), 4.27-4.28 (2H,m), 4.81-4.82 (2H, m), 5.78-5.80 (1H, m), 7.00-7.08 (3H, m), 7.65-7.69 (2H, m), 7.97 (1H, d, J = 5.1 Hz), 8.20 (1H, s).
According to the analysis of related databases, 876919-08-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; QUANTICEL PHARMACEUTICALS, INC.; CHEN, Young, K.; KANOUNI, Toufike; NIE, Zhe; STAFFORD, Jeffrey, Alan; VEAL, James, Marvin; WALLACE, Michael, Brennan; WO2014/100818; (2014); A1;,
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