Adding a certain compound to certain chemical reactions, such as: 136888-21-6, 2-Chloro-5-fluoro-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Chloro-5-fluoro-3-nitropyridine, blongs to pyridine-derivatives compound. Quality Control of 2-Chloro-5-fluoro-3-nitropyridine
2-Chloro-3-nitro-5-fluoropyridine (353 mg, 2.0 mmol),Copper powder (317 mg, 5.0 mmol) was added to 6 ml of anhydrous DMF solution under a nitrogen atmosphere.Heated to 150 C for 10 hours under nitrogen protection,After adding ammonia water and extracting with ethyl acetate, after removing the low boiling point solvent,Separation by column chromatography (silica gel, eluent: ethyl acetate / petroleum ether = 1/10)A pure 3-amino-3′-hydroxy-(2,2′)-bipyridine derivative was obtained.The product was a pale yellow solid with a yield of 54%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,136888-21-6, 2-Chloro-5-fluoro-3-nitropyridine, and friends who are interested can also refer to it.
Reference:
Patent; Nanchang University; Cai Hu; Liu Qing; Xie Yongfa; Yue Shusheng; (11 pag.)CN107935924; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem