Application of 19337-97-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19337-97-4, name is trans-3-(3-Pyridyl)acrylic acid, molecular formula is C8H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of (E)-3-(pyridin-3-yl)acrylic acid (0.40 g, 2.68 mmol, 1 eq) in DMF dry (4.0 mL), ammonium chloride (0.85 g, 16.10 mmol, 6 eq), HOBt (0.52 g, 3.86 mmol, 1.44 eq), EDCI (0.74 g, 4.20 mmol, 1.44 eq) and N-methylmorpholine (0.43 mL, 3.90 mmol, 1.44 eq) were subsequently added. The reaction was stirred at room temperature, under nitrogen for 3 h. After adding water, the reaction was filtered off through a neutral alumine oxide pad, washing with EtOAc/MeOH 9:1 (3 * 10 mL). The filtrate was evaporated and the residue was purified by column chromatography, using EtOAc/MeOH 9:1 as eluant to give 5 as white solid after crystallization with EtOAc (0.34 g, 85%). Mp 154-156 C. 1H NMR (300 MHz, CD3OD) delta 8.71 (d, J = 2.1 Hz, 1-H), 8.51 (dd, J = 4.9/1.5 Hz, 1-H), 8.05 (dt, J = 7.9/1.8 Hz, 1-H), 7.57 (d, J = 15.9 Hz, 1-H), 7.47 (dd, J = 7.9/4.9 Hz, 1-H), 6.77 (d, J = 15.9 Hz, 1-H); 13C NMR (75 MHz, CD3OD) delta 168.6, 149.5, 148.2, 137.1, 135.0, 131.5, 124.3, 123.1; MS (ESI) m/z 149 (M + H)+; IR (KBr) 3151, 3036, 2370, 1683, 1604, 1400, 980 cm-1. Anal. Calcd for C8H8N2O: C, 64.85; H, 5.44; N, 18.91. Found: C, 64.54; H, 5.12; N, 19.20.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 19337-97-4, trans-3-(3-Pyridyl)acrylic acid.
Reference:
Article; Galli, Ubaldina; Mesenzani, Ornella; Coppo, Camilla; Sorba, Giovanni; Canonico, Pier Luigi; Tron, Gian Cesare; Genazzani, Armando A.; European Journal of Medicinal Chemistry; vol. 55; (2012); p. 58 – 66,9;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem