Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8) was written by Sreekantha, Ratna Kumar;Mussari, Christopher P.;Dodd, Dharmpal S.;Pasunoori, Laxman;Hegde, Subramanya;Posy, Shana L.;Critton, David;Ruepp, Stefan;Subramanian, Murali;Salter-Cid, Luisa M.;Tagore, Debarati Mazumder;Sarodaya, Sanket;Dudhgaonkar, Shailesh;Poss, Michael A.;Schieven, Gary L.;Carter, Percy H.;Macor, John E.;Dyckman, Alaric J.. And the article was included in ACS Medicinal Chemistry Letters in 2022.Product Details of 131747-45-0 This article mentions the following:
The toll-like receptors (TLRs) play key roles in activation of the innate immune system. Aberrant activation of TLR7 and TLR8 pathways can occur in the context of autoimmune disorders due to the elevated presence and recognition of self-RNA as activating ligands. Control of this unintended activation via inhibition of TLR7/8 signaling holds promise for the treatment of diseases such as psoriasis, arthritis, and lupus. Optimization of a 2-pyridinylindole series of compounds led to the identification of potent dual inhibitors of TLR7 and TLR8, which demonstrated good selectivity against TLR9 and other family members. The in vitro characterization and in vivo evaluation in rodent pharmacokinetic/pharmacodynamic and efficacy studies of BMS-905 is detailed, along with structural information obtained through X-ray cocrystallog. studies. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Product Details of 131747-45-0).
(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 131747-45-0