Srivastava, Payal; Shukla, Manjulika; Kaul, Grace; Chopra, Sidharth; Patra, Ashis K. published the artcile< Rationally designed curcumin based ruthenium(II) antimicrobials effective against drug-resistant Staphylococcus aureus>, Synthetic Route of 366-18-7, the main research area is curcumin ruthenium complex antimicrobial drug resistant Staphylococcus aureus.
Two new curcumin containing octahedral ruthenium(II) polypyridyl complexes, viz. [Ru(NN)2(cur)](PF6) [NN = bpy (1), phen (2)], were designed to explore the antimicrobial activity against ESKAPE pathogens, especially with the Gram-pos. drug resistant S. aureus. Solid-state structural characterization by single-crystal X-ray crystallog. shows the RuII-center in a distorted octahedral {RuN4O2} geometry. The tested compounds showed significant inhibitory activity and high selectivity (MIC = 1μg mL-1, SI = 80) against a wide variety of methicillin and vancomycin-resistant S. aureus strains. Compound 1 exhibited strong anti-biofilm activity (48% reduction of biofilm) at 10× MIC compared to the other approved drugs. The murine model of Staphylococcus infection significantly reduced the mean bacterial counts when treated with complex 1 compared to vancomycin, demonstrating its antimicrobial potential in vivo.
Dalton Transactions published new progress about Antibiofilm agents. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, Synthetic Route of 366-18-7.