Stahlberger, M.; Steinlein, O.; Adam, C. R.; Rotter, M.; Hohmann, J.; Nieger, M.; Koeberle, B.; Braese, S. published an article in 2022. The article was titled 《Fluorescent annulated imidazo[4,5-c]isoquinolines via a GBB-3CR/imidoylation sequence – DNA-interactions in pUC-19 gel electrophoresis mobility shift assay》, and you may find the article in Organic & Biomolecular Chemistry.Electric Literature of C6H4BrNO The information in the text is summarized as follows:
The development of a sequential synthesis route towards annulated imidazo[4,5-c]isoquinolines comprising a GBB-3CR, followed by an intramol. imidoylative cyclization was reported. X-Ray crystallog. revealed a flat 3D structure of the obtained polyheterocycles. Thus, their interactions with double-stranded DNA was evaluated by establishing a pUC-19 plasmid-based gel electrophoresis mobility shift assay, revealing a stabilizing effect on ds-DNA against strand-break inducing conditions.2-Bromonicotinaldehyde(cas: 128071-75-0Electric Literature of C6H4BrNO) was used in this study.
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Electric Literature of C6H4BrNO