Novel 18β-glycyrrhetinic acid analogues as potent and selective inhibitors of 11β-hydroxysteroid dehydrogenases was written by Su, Xiangdong;Lawrence, Harshani;Ganeshapillai, Dharshini;Cruttenden, Adrian;Purohit, Atul;Reed, Michael J.;Vicker, Nigel;Potter, Barry V. L.. And the article was included in Bioorganic & Medicinal Chemistry in 2004.Category: pyridine-derivatives This article mentions the following:
Extensive structural modifications to the 18β-glycyrrhetinic acid template are described and their effects on the SAR of the 11β-hydroxysteroid dehydrogenase isoenzymes type 1 and 2 from the rat are investigated. Isoform selective inhibitors have been discovered and N-(2-hydroxyethyl)-3β-hydroxy-11-oxo-18β-olean-12-en-30-oic acid amide is highlighted as a very potent selective inhibitor of 11β-hydroxysteroid dehydrogenase 2 with an IC50 = 4 pM. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Category: pyridine-derivatives).
3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Category: pyridine-derivatives