Novel carbazole sulfonamide derivatives of antitumor agent: Synthesis, antiproliferative activity and aqueous solubility was written by Sun, Lianqi;Wu, Yanbin;Liu, Yonghua;Chen, Xiaofang;Hu, Laixing. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Formula: C7H10N2O2 This article mentions the following:
The current optimization of IG-105 on the carbazole-ring provided a series of new carbazole sulfonamides derivatives All of the compounds have been evaluated against HepG2 cells (hepatoma cancer) for antiproliferative activity. Compounds that showed activity better or comparable to that of IG-105 vs. HepG2 were evaluated against MCF-7 (breast cancer), MIA PaCa-2 (pancreatic cancer), and Bel-7402 (hepatoma/liver cancer) for antiproliferative activity. Of the seven compounds selected for further study five were found to give IC50 values against the four cell lines comparable to those for IG-105. Two compounds (I and II) were more active than IG-105 and their activity against HepG2 and MCF-7 (IC50:0.01-0.07 μM) approached that of the pos. controls podophyllotoxin (podo) and CA-4. Most of compounds showed aqueous solubility (0.11-19.60 μg/mL at pH 7.4 and 2.0) better than IG-105. These promising results warrant further development of new compounds I and II as potential potent antitumor drug candidates. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Formula: C7H10N2O2).
3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Formula: C7H10N2O2